Category: Aging,elderly, discomfort, disease

10 facts: The link between obesity and brain function🧠

by drjurisharma, posted in Adult over 50, Adults, young people,, Aging,elderly, discomfort, disease, Antioxidant,anti inflammatory, immune boosting, anti cancer, Blog, body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, brain, emotional health, Food, Food, eating habits, eating disorders, eating preferences, choices, culture, traditions, travels, family, Fresh, local, produce, gut health, gut bacteria, hormones, Gastrointestinal, GI tract, healing, health, Heart disease, Infection,inflammation, Obesity, brain fog, brain function, fatigue, depression, anxiety, diabetes, disease, neurological disorders, memory, metabolic disorders, Science, self healing, wellness

1.Research has already stated that obesity is a risk factor for neurocognitive decline. Obesity has become a widespread lifestyle disease that affects individuals regardless of age, gender, race, or culture. Many studies are being conducted on the relationship between obesity, defined as an excessive accumulation of fat, and brain function. Research has shown that structural changes in the brain are quite common among elderly obese individuals, particularly in the form of cerebral atrophy in grey matter and alterations in white matter volume. Notably, there is a reduction in the volume of the frontal lobe, hippocampus, thalamus, and anterior cingulate gyrus. Changes in brain structure can also occur in younger obese individuals.

2.BDNF (Brain-Derived Neurotrophic Factor): Adverse effects of Brain-Derived Neurotrophic Factor (BDNF) have been linked to lifestyle and diet choices. Low levels of BDNF, which affect neuronal plasticity, are associated with obesity and diets high in sugar or fat. Studies have shown that a high-fat diet, which leads to increased body weight, is related to reduced BDNF levels in the prefrontal cortex. This reduction can result in learning difficulties and impaired food intake control. Additionally, elevated serum leptin levels in obese individuals can lead to changes in the structure of the hippocampus and negatively impact memory performance.

3.Inflammation: When there in increased accumulation of fat tissues, they trigger chronic inflammatory responses, chemicals (cytokines) which crosses the blood brain barrier and reaches the brain cells, thus neuro-inflammation starts. The inflammation process spreads in the brain, damaging the cells, mitochondrial malfunctions which causes oxidative stress, brain immune cells (microglia) becomes hyperactive causing inflammation which can be localised or extensive. The hypothalamus, which controls appetite, is affected, creating a vicious cycle of weight gain. The hippocampus and Amygdala are affected, which causes issues in memory and emotion control.

4. Brain metabolism: Obesity can greatly affect brain metabolism by disturbing core functions such as :

• Obesity can disturb the brain’s insulin sensitivity, which in turn disrupts appetite control and impairs neuronal energy production.

• Mitochondrial dysfunction and low energy production in brain cells can increase oxidative stress and the release of harmful toxins, leading to cellular damage.

• Neuro-inflammation spreads due to the release of inflammatory chemicals like cytokines from visceral fat, leading to an increased risk of cognitive decline, dementia, depression, anxiety and diseases like Alzheimer’s disease.

5. Obesity and insulin resistance: In a healthy individual, insulin acts as an appetite-suppressing hormone on the brain. Studies show that obesity plays a key role in disrupting insulin sensitivity, causing impaired appetite control, resulting in metabolic disorders like type 2 diabetes. Studies have already linked obesity to diseases like heart attacks and cancers. Apart from appetite regulation, insulin in the brain helps in the co-ordination of fat distribution by promoting healthy subcutaneous fat storage instead of unhealthy visceral fat storage. Obesity leads to brain insulin resistance, causing an increase in visceral fat, increased food cravings, overeating, anxiety, depression and further weight gain.

6. Behaviour changes: Dealing with obesity is a gradual process which requires lifestyle changes, dietary changes, physical activity, counselling and a constant support system. Some of the key pillars are :

• Reduction of calories on a daily basis by 500 to 1000 calories. Switching to a calorie deficit diet like whole grains, vegetables, lentils and fish. Portion control and balanced meals are necessary.

• Gradually increasing the level of physical activity like walking, jogging, swimming, weight training.

• Counselling and a support system, including family and peers, to address emotional triggers, anxiety, and stress. A good quantity of sleep is important.

• Self-motivation, self-monitoring of daily calorie intake, routine weight assessment, monitoring physical activity levels and off-course mindfulness practices like meditation and nature bathing.

• Metabolic surgery in case of severe obesity, recommended by professionals.

7.Cognitive functions: In obesity, there are enough studies to show that there is a risk of cognitive decline. There are several ways to improve cognitive functions, such as:

• Controlling neuro-inflammation by medically managing any signs of systemic inflammation, controlling blood sugar levels and managing triggers like stress and anxiety.

• Dietary changes like avoiding high-sugar foods completely, processed foods and focusing on nutrient-rich, low-calorie foods.

• Exercises like cardio workouts to increase blood flow to the brain, which helps flush toxins, help to grow the size of the hippocampus to improve memory.

• Continuous physical activity by avoiding sitting for long hours; constant physical activity apart from routine exercise to clear brain fog. Weight training regularly, which helps to boost BDNF. Improving sleep quality.

• Trying to adopt intermittent fasting, which can help reduce brain inflammation.

8. Rewiring the brain for behavioural modification: To break a behaviour pattern which has been practiced for a long time is a difficult task, requiring patience and effort. Understanding and self – assessment are key pillars.

• Understanding the stress triggers, hunger signals, and habit loops to know the emotions behind them. To change neural pathways, repetition of a corrective behaviour pattern each time such a trigger arises is necessary to rewire the brain.

• Practising mindfulness to activate control of your brain to quiet the default false hunger signals and stress triggers.

• Changing eating habits to healthier options like whole grains, fibre-dense foods, portion control and cutting down on sugary or highly processed food to prevent dopamine spikes.

9. Managing hunger signals and habit loops: Not all hunger signals are real; some of them are false alarms just to activate your brain reward system. Some of the strategies are such as :

• Drinking water or sipping green tea or black coffee to fill the stomach.

• Eating small portions of meals every 3-4 hours instead of heavy meals.

• Practise physical activity throughout the day, like light exercise, walking and avoid sitting for long hours.

• Engage in activities and hobbies apart from routine chores or office work to keep the mind distracted from hunger signals.

• Lower stress by practising deep breathing exercises.

10. Takeaway: Research has shown that a high Body Mass Index (BMI) is associated with cognitive decline, reduced brain volume, and tissue atrophy in the frontal lobes and hippocampus. Excess weight also contributes to the degradation of the corpus callosum, which connects the two hemispheres of the brain. However, it is possible to reverse these effects by losing weight and making lifestyle changes, including adjustments to behaviour and eating habits. This process is gradual but rewarding and requires self-motivation, as well as support from family and peers, to break old habits and develop new neural pathways. In extreme cases, medical interventions such as anti-obesity medications or surgical procedures may be necessary if clinically recommended.

Thanks for reading.

Peace and love 🙏

10 facts: Hyaluronic acid (HA) is a vital prebiotic fibre 🫧

by drjurisharma, posted in Adults, young people,, Aging,elderly, discomfort, disease, antioxidant, Antioxidant,anti inflammatory, immune boosting, anti cancer, Blog, butyrate, dairy, curd, yogurt, eyes, Food, Fruits, veggies, berries, healing, health, Hyaluronic acid, prebiotic fibers, skincare, joints, eyes, bones, gut bacteria, gut health, hydration, skin protection, skin products, cosmetic products, Infection,inflammation, Nature,, Science, self healing, Supplement, wellness

1. Structurally, all fibres are polymers of sugar molecules. Likewise, hyaluronic acid is also a polymer of sugar molecules: N-acetyl-D-glucosamine and glucuronic acid. It is naturally produced in the body, while dietary sources of hyaluronic acid are essential for the body’s optimal functioning. Though hyaluronic acid has many beneficial effects, it’s most important effect is the water holding capacity by binding water molecules, which in turn help in retaining moisture, lubrication, facilitate immune system mediators to provide protection. Generally, most women are aware of this compound as a hydrating agent for skin, as it is used widely in skin and cosmetic products.

2. Though hyaluronic acid is produced in the body, dietary sources of hyaluronic acid are necessary as they bridge the gap between naturally formed HA and the optimal amount required. HA has many beneficial effects in the body such as:

• The eyes naturally have hyaluronic acid. Additional quantity from diet can help further in lubricating eye tissues and helps in protecting vision.

• Lubricates the joints of knees and hips, increasing synovial fluid, protecting the cartilage, and preventing arthritis.

• Adding more hyaluronic acid in the diet can help in skin and other organs by hydration and maintaining the elasticity.

• Hyaluronic acid helps in increasing butyrate-producing bacterial species in the gut, which are very important in reducing insulin resistance and HbA1c. An additional quantity added through diet can further enhanced the ability.

• Improves vaginal dryness and atrophy, so ingested hyaluronic acid (HA) can prove very helpful in menopausal women.

3. Hyaluronic acid in Prebiotic fibre: HA in the human body is found to be part of the extracellular matrix, which binds the cells together and helps in the passage of nutrients and oxygen to the cells. It provides elastoviscocity to the connective tissues, helps in hydration of tissues, acts as a lubricant in synovial fluids around the joints, and provides hydration to the eye tissues as well. HA also helps in endogenous intercellular activities, such as antioxidant activities and free radical scavenging. HA sources from plant foods can be both soluble and insoluble fibres. Both types of fibre function as prebiotic and improve the environment of the gut microbiome. Therefore, research has shown that adequate intake of fibres (daily intake of 25-35 gm) can provide additional sources of HA, which can enhance the growth of good bacteria, suppress bad bacteria and reduce gas and bloating.

Gut health

4. Gut health benefits: Natural sources of hyaluronic acid through different dietary sources can be immensely beneficial to gut health. Some of the common benefits:

• Soluble fibres can slow down digestion and delay hunger, while insoluble fibres can maintain bowel movements and form the stool bulk. It helps to prevent gas and bloating.

• Prebiotic fibres enhances the growth of beneficial bacteria by producing short chain fatty acid.

• Improvement of gut environment can reduce body’s inflammation, strengthen immune system.

• Strengthening the intestinal gut lining barrier by forming tight junctions between the epithelial cells.

• HA in fibres help in providing hydration and producing mucin that protects the mucosal lining of intestines.

Skin care

5. Hyaluronic acid as skin hydrating agent: HA has been widely used in many skin care and cosmetic products for a long time. The amazing benefits to skin health are as follows:

• HA is the most important compound in the body, including the skin, which helps in maintaining cellular hydration and tissue integrity.

• Reduces the wrinkles by filling the skin cells with water giving the plum skin.

• Maintain the viscoelasticity in the skin, keeping it soft and bouncy.

• Strengthen the natural skin lining barrier and prevent from acne and skin sensitivity problems.

Knee Joint

6. HA as supplement: Hyaluronic acid is naturally produced and found in the body in different areas, especially in the joints, bones, connective tissues, extracellular matrix, skin and eyes. HA is used as a supplement in the form of oral tablets, injectables, topical agents, eye drops and intimate creams and gels. Usually, over-the-counter hyaluronic acid pills, skin gel, creams, andeye drops are safe. Prescription-drug injectable forms should be used under medical supervision. The conditions for which hyaluronic acid is used as supplements are:

• Maintaining eye health, dry eyes.

• Skin health, dryness, actinic keratosis, scleroderma, anti-wrinkle agents, hydrating agents.

• Joints to reduce stiffness, arthritis, soft tissue injuries.

• Asthma as prescribed medication.

• Interstitial cystitis.

• Wound healing.

Skincare products

7. Hyaluronic acid with Vitamin C: Pairing of hyaluronic acid and vitamin C is recommended as they work in synergy, though their individual functions are different. Skin and cosmetic products with this pairing are amazing for skin dryness and ageing issues like wrinkles. HA is mostly used for face application as a hydrating agent, improves skin elasticity, reduces wrinkles and repairs skin damage. Vitamin C acts as an antioxidant and protects the skin from damage from UV rays and pollution.

Vegetarian food

8. Dietary sources of HA: Both non-vegetarian and vegetarian sources are found in nature which provide hyaluronic acid. Vegetarian sources can indirectly provide nutrition and facilitate the body to produce HA. Non-vegetarian sources provide HA directly to the body. Sources are such as:

• Vegetarian sources are leafy greens, root vegetables, citrus fruits, soy products and nuts and seeds.

• Non-vegetarian sources are bone broth and organ meat.

Bone broth

9. HA in dairy products: HA has been found to have a prebiotic effect, which is beneficial for gut health and other amazing benefits. It is added to dairy products as a food additive. In dairy products like milk, yoghurt, and ice cream, it helps to retain moisture, stabilises the milk protein, improves the viscosity, and increases the thickness, making it creamier. It also reduces the milk syneresis, or separation of whey, thereby lengthening the shelf life. Moreover, it has amazing health benefits too.

Skin hydration

10. Takeaway: Hyaluronic acid is a naturally occurring substance in the body in different areas like joints, connective tissue, skin, cartilage, and bones. It acts as a humectant, retaining water in the tissue, keeping them hydrated and moist. So, it has some amazing benefits like joint lubricant, prebiotic as they enhance the growth of good bacteria, wound healing, skin hydration, reduces and repairs skin damage, and anti-ageing effects. To get the optimal supply of HA, many use HA as a supplement, topical agents, creams, lotions and injectables (off course when prescribed). There are many dietary sources of both vegetarian and non-vegetarian foods which can help increase the body’s requirement of HA. It is in fact, a very essential sugar molecule for overall health.

Thanks for reading.

Peace and love 🙏

10 facts: Is Sarcopenia reversible?

by drjurisharma, posted in Adults, young people,, Aging,elderly, discomfort, disease, body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, healing, health, life, Physical activity, exercise, strength training, walking, meditation, Sarcopenia, elderly, muscle loss, chronic fatigue, disease, wellness

1.Sarcopenia is a musculoskeletal condition mostly common in the elderly population where there is progressive loss of muscle mass. However, today, it can also be linked to certain chronic conditions and lifestyle habits, where the process of muscle loss starts much earlier, even in younger populations, between 30 and 40 years old. Sarcopenia impacts on inability to perform regular daily activities, frequent falls, fractures, reduces quality of life, ageing progression and risks of more complications related to death.

2.The rate of muscle loss increases with advancing age. People with chronic diseases are more prone to sarcopenia than an otherwise normal healthy individual. The process of muscle loss is often noticeable with ageing, but it can be slowed by implementing lifestyle changes. Sarcopenia can affect quality of life as:

• Disability.

• Loss of independence.

• More visits to hospitals.

• Expensive, as increase health care costs, or very likely, a need of institutionalized care can arise.

• Risk of surgical complication.

• Lower rates of survival.

3.As ageing progresses, the muscles of the body lose mass as the body doesn’t produce enough protein. Ageing also brings out hormonal changes like lower levels of testosterone and insulin growth factor, which can further contribute to sarcopenia. There are many risk factors of sarcopenia such as:

• Inadequate protein intake or malnutrition.

• Reduce protein conversion as age advances.

• Lower levels of growth hormones, testosterone, insulin-like-growth factor.

• Increase inflammation.

• Diabetes, insulin resistence.

• Chronic kidney and liver diseases.

• Obesity.

• Cancer, HIV

• Chronic obstructive pulmonary disease.

• Rhematoid arthritis, lupus, osteoporosis.

• Congestive heart failure.

Sedentary lifestyle

4.Important lifestyle factors, including environmental risk factors, can contribute to the early onset and progression of sarcopenia:

• Sedantery lifestyle, lack of exercise.

• Bedridden, bedrest.

• Loss of mobility due to paralysis, neurological causes.

• Improper diet.

• Dental and oral problems.

5. Sarcopenia greatly affects the quality of life. Common symptoms can be :

• Shrinking muscles, muscle atrophy.

• Muscle weakness.

• Inability to perform daily activities.

• Difficulty walking, climibing stairs.

• Loss of stamina and loss of balance.

• Frequent falls, fractures.

• Poor posture, hunched or stooped.

Weight training

6.Sarcopenia is diagnosed by medical history, visible signs of muscle loss and a series of physical tests and examinations.

• Physical tests like walking speed assessment, grip strength test, chair stand test. SARC-F screening tests.

• Blood tests like hormonal levels, vitamin D levels, markers of inflammation.

• Imaging tests like Xray Absorbptiometry, Bio impedence analysis (BIA).

7.Consultation with a Physician is important when there are visible signs of muscle loss, fatigue and difficulty performing routine physical activity. Consider visiting a Specialist when you have signs:

• Walking slowly, feeling fatique while walking.

• Difficulty getting up from chair, climb stairs, lift heavy objects.

• Loss of balance, frequent falls.

• Thinning of arms and legs.

8. Usually, bringing about lifestyle changes and improving diet can make a great difference in improving or bringing positive changes in Sarcopenia patients. Potential treatments of Sarcopenia can be:

• Treating the underlying conditions.

• Exercise routine as per individual requirements like resistence training, aerobic exercises.

• Nutritional interventions, like increasing protein intake like meat, fish, eggs, soy protein. Nutritional supplements like vitamin D, Omega 3 fatty acid and creatine.

9.There are ways which can slow down the process of muscle loss and maintain muscle mass as age advances:

• As ageing progresses, the body’s ability to synthesise and break down protein reduces, which is known as anabolic resistance. So, the protein intake should be increased to 1-1.3/kg of body weight daily.

• Most important is maintaining an active lifestyle with regular exercise of walking, resistance training to maintain lean muscle mass.

• Regular sleep pattern.

• Nutritional supplements like Vitamin D, omega-3 fatty acids, and creatine are essential.

Adequate sleep

10.Last but not the least, the process of ageing and muscle loss are inevitable with time, but making changes in lifestyle habits and diets can bring about positive changes and delay the process. Studies have greatly shown that the quality of life and lifespan can be improved by effective ways of improving diet with high-quality protein, strength and resistance training, walking daily, reducing stress and adequate sleep.

Thanks for reading.

Peace and love 🙏

10 facts : What is SIBO or blind loop syndrome ?

by drjurisharma, posted in Aging,elderly, discomfort, disease, Blog, healing, health, SIBO, intestinal disease, IBS, diabetes, abdominal pain, bloating,gas, pain,, Supplement, Vitamin Deficiency, mental health,, wellness

1. SIBO, abbreviated as small intestinal bacterial overgrowth, is a condition where there is an overgrowth of bacteria that are not supposed to be present in the normal scenario in that part of the digestive tract. This occurs particularly following a disease or abdominal surgery, when the passage of food and waste becomes slower, creating a breeding ground for bacterial overgrowth.

2. When the wrong types of bacteria overgrow in the small intestine, they feed on the nutrients and food for the otherwise beneficial bacteria, which can lead to abnormal symptoms in gut health. These wrong types of bacteria can feed on the protein and vitamin B12, bile salts which are supposed to support the digestion of fats. In normal circumstances, the small intestinal bacteria digest the carbohydrate and convert it to short-chain fatty acids and gas. Therefore, when there is overgrowth of bacteria, more gas and toxins are produced in the gut leading to many GI symptoms and malnutrition in the long run.

3.The prevalence of SIBO is about 80-90% in cases of irritable bowel disorder, intestinal dysmotility , pancreatitis and chronic systemic conditions. It is more prevalent in the elderly and female population. Usually, the incidence increases with age and the presence of chronic intestinal disorders and dysmotility. SIBO is considered by clinicians as a differential diagnosis of other gastrointestinal non-specific disorders as the actual aetiology is still unknown.

4. The GI symptoms following SIBO are many:

• Gas, bloating, nausea

• Abdominal pain, distention

• Constipation

• Indigestion

• Weight loss, fatigue

• Watery or mucus in poop.

• Hard or lumpy poop.

5.Unexpected and systemic signs may appear due to excess toxins released in bloodstream

(endotoxemia) in SIBO:

• Food intolerence

• Fatty liver

• Fibromyalgia

• Irritable bowel syndrome

• Anxiety, depression, suicidal thoughts

• Endometriasis

• Disruption of mentrual cycle.

• Prostate diseases.

• Atrial fibrillation

• Siezure

6.Though the actual cause of SIBO is unknown, hence, there are several underlying conditions which can be the risk factors:

• Ageing: As age progresses, there may be changes in microflora, degeneration of acid-producing gastric cells, intestinal dysmotility which may lead to bacterial overgrowth.

• Irritable bowel syndrome leads to dysmotility, delayed transition of food, wastage.

• Chonic metabolic diseases like uncontrolled diabetes,

• Celiac disease,

• Lupus,

• Scleroderma,

• Pancreatitis,

• Chronic kidney diseases

• Fatty liver,

• Structural problems in the intestine due to gastric surgery, partial blockage, antibiotics or narcotic drugs overuse.

7. Several complications of SIBO can eventually worsen gut health if left untreated:

• Inadequate digestion and absorption of fat, protein, carbohydrate: Since, overgrowth of bacteria in the small intestine damages the bile salts so the fat remains undigested. The mucous lining of the intestines is damaged too by the excess bacteria causing poor absorption of carbohydrate, fat and protein. Therefore, there is malnutrition, diarrhoea, and weight loss.

• Vitamin B12 deficiency: As the fat remains undigested, the fat-soluble vitamins A, D, E, and K remain unabsorbed. Vitamin B12 which is synthesised in the small intestine is completely affected So, the individual may suffer from vitamin B12 deficiency. Therefore, due to B12 deficiency, nervous system functioning is affected, and blood cell production is lowered. There can be irreversible damage to the nervous system in the long run.

• Calcium absorption: Bacterial overgrowth damages the intestine slowly, resulting in poor absorption of calcium thereby affecting bone health. Weakened bones, prone to fractures, and osteoporosis are common. Kidney stones are also common in cases of poor calcium absorption.

8.There are no standard diagnostic tests for SIBO. The clinical symptoms of SIBO can be nonspecific. Usually, a carbohydrate breath test is considered which is inexpensive and non-invasive. A bacterial culture of jejunal aspirate of more than 1000 units/ml can support the diagnosis. Upper endoscopy is invasive but is done in patients to further support the diagnosis. Laboratory findings like vitamin levels, malnutrition markers are considered to support the diagnosis. Only, in rare cases is, biopsy of the small intestine done. Imaging tests like CT, MRI are done to rule out intestinal abnormalities.

9.Since the condition of SIBO is complex and can be involved with multiple underlying conditions, it is very difficult to manage and treat such cases. The treatment is mainly symptomatic like changing diet, lifestyle, and antibiotics to reduce the bacterial colonies. The recurrence of SIBO is also common so repeated courses of antibiotics are necessary. Supplementation of vitamins in certain cases is required. Surgery is only necessary in case of small intestinal abnormality, diverticula, bowel obstruction, or Crohn’s disease.

10.Again there is no standard diet for every individual who suffers from SIBO. It is individual-specific depending on symptoms and underlying conditions. The goal of diet change is to assist in the treatment and lower the symptoms. The diet should be low in carbohydrates, low in fat, and moderate to low in fibre. Processed sugar items, dairy, whole grains, deep-fried items, and raw vegetables should be avoided. Generally, probiotic-rich food, meat or fish, rice, cooked vegetables, plenty of fluid/water/soups and vitamin supplementation are recommended by the experts.

Thanks for reading.

Peace and love 🙏