Hi everyone ✋

1.The lateral hypothalamus and prefrontal cortex produce a hormone called Orexin, also known as hypocretin. It is produced in two forms like Orexin A and Orexin B. It has various functions related to Central Nervous System. It helps in regulating important functions like sleep-wake cycle, arousal state, energy homeostasis, feeding behaviour, emotions, mood and cognition.
2.Sleep: Orexin is usually released in the daytime and keeps us awake. It stimulates those neurons which in turn help in the release of neurotransmitters like serotonin, dopamine and nor- epinephrine. In case of individuals with orexin deficiency, are usually diagnosed with narcolepsy, insomnia, sleep imbalance, daytime sleepiness and cataplexy.

3.Stress regulator: Orexin is highly responsive to environmental stimuli and our mood. When in stress situations ,the orexin neurons stimulate the body’s response to increase heart rate, blood pressure and disturb the resting state.

4.Obesity: It is a result of the influence of orexin-producing neurons on energy metabolism.Orexin deficiency in the body can lead to slowing down energy metabolism, physical inactivity, and excessive weight gain, even if the calorie intake is low.
5.Mood: Orexin has an influence on mood through its impact on the hippocampus. Abnormal orexin activity has been related to mental health conditions like depression, PTSD, anxiety and addiction. Deficits in orexin influence can result in hippocampus problems such as learning disability and memory deficits, as it also promotes the development of neurons in the hippocampus.

6.Narcolepsy: Orexin helps us stay awake during the day. So, people with orexin deficiency suffer from narcolepsy. They have daytime sleepiness and sleep paralysis. Mostly, these type of individuals can also suffer from cataplexy. The person is unable to move for a short time even if he is awake or about to fall asleep. It is usually occurs in a conscious state of mind and triggered by strong emotions like being angry, or laughing.

7.Alzheimer’s Disease: Several studies show that orexin has direct connection with sleep, cognition and as a stress regular. So it does play a significant impact on Alzheimer’s disease pathology. An increase level of orexin has been found in cerebrospinal fluid of people with Alzheimer’s. So, they usually have circadian cycle disorders, daytime sleepiness and cognition problems. However, researches are still going on for further prospectives of using orexin antagonist receptors as a potential treatment alternative.

8.Heart: Lack of sleep and insomnia have a direct impact on cardiovascular health and hypertension. Studies show that increased levels of orexin stimulation can elevate blood pressure and heart rate. Both orexin A and B receptors have a direct role in the regulation of sympathetic nervous system. Therefore orexin antagonist receptors might be a therapeutic option for hypertension.
9.Orexin levels: High levels of orexin may lead to sleep disorders, stress prone and eating disorders. But lack of orexin or loss of orexin in brain injury may lead to narcolepsy or other sleep disorders. The normal level of orexin found in cerebrospinal fluid in a healthy individual is around 250 – 500 pg/ml.

10.Food: Optimal level of orexin can be provided in a healthy individual by regular intake of fermented food like pickles or sauerkraut. Having excessive sugar or carbohydrate rich food can inhibit orexing production.
Thanks for reading.
Peace and love 🙏
































