Category: meditation, inflammation, disease, physical health, mental health, wellbeing

10 facts: Gut-brain impact on sleep-wake cycle šŸ˜“

by drjurisharma, posted in Blog, brain, Gut brain axis, gut health, brain, sleep pattern, sleeping habits, insomnia, sleep deprivation, gut health, gut bacteria, hormones, Gastrointestinal, GI tract, healing, health, meditation, inflammation, disease, physical health, mental health, wellbeing, self healing, wellness

1. The gut is known as the ā€œsecond brainā€ as there is a 2 way connection between the brain and the gut via the vagus nerve. The gut microbiome produces neurotransmitters that can travel and send signals through the nervous system, aļ¬€ecting our mood, behaviour, emotions, and sleep. The gut and brain also send signals through hormonal pathways and the immune system.Therefore, the gut-brain axis plays a crucial role in overall well-being, and any disruption to this axis can lead to issues such as disturbances in gut health, neurological disorders, inflammation, and sleep disturbances.

2. Through the gut-brain axis, there is a mutual continuous communication between the brain and the gut. The gut microbiome produces a considerable amount of neurotransmitters and hormones like melatonin, which influence the circadian rhythm and mood. Both the sleep cycle and gut microbiota are influenced by factors like daylight, stress and diet. Hence, if there is unhealthy gut microbiome, there will be disruption in the sleep-wake cycle, while poor sleep will lead to disturbances in the gut microbiota.

Gut microbes

3. Inflammation: Poor sleep can cause disturbances in gut health, which will lead to a pro-inflammatory state in the body. The gut microbiome composition and diversity are disrupted, creating an imbalance. Gut health issues like irritable bowel disorders, leaky gut, and hormonal issues can worsen in the body. Lack of sleep can also aļ¬€ect gut permeability and lead to nutritional absorption interference. Not only gut health, but poor sleep can also aļ¬€ect the metabolic pathways, immune state and neural pathways.

Gut microbiota

4. Research has shown that through the gut-brain axis, there is a bidirectional communication between the gut microbiota and the central nervous system. Beneficial bacteria like Lactobacillus and Bifidobacterium, which increase serotonin and gamma-aminobutyric acid production, help in the quality and lengthening of sleep. On the other hand, lack of sleep can lead to a reduction of beneficial bacterial flora, an imbalance in the microbiota, which includes probiotics, prebiotics, and postbiotics.

5. Studies have revealed that sleep, a natural physiological process, is important in maintaining a healthy gut microbiota and vice versa. Poor sleep patterns, insomnia, and sleep deprivation not only influence the emotional and cognitive well-being but also cause an imbalance in gut bacteria and gut flora. Therefore, there is a direct connection between sleep disorders and gut health, and resolving gut issues has a therapeutic eļ¬€ect.

6. The equilibrium of the sleep-wake cycle with the well-being of gut microbiota is very delicate and needs to be maintained by external factors. The balance can be easily disturbed by factors like stress, poor diet, lack of exercise, and poor sleep habits. Studies have shown that this reciprocal correlation shows sleep as the primary modulator between gut health issues and sleep length and quality.

7. Growing research has shown that the gut-brain axis plays a crucial role both directly and indirectly in the shift of composition of gut-microbiota with the development of sleep disorders like insomnia, sleep fragmentation, sleep deprivation and sleep apnea. Human studies have shown that 60-70% of the composition of gut microbiota depends on the oscillatory rhythm of the circadian rhythm.

8. Though Melatonin, a sleep hormone, is known to be produced by the pineal gland, it is actually the gut which is the primary source of it. This hormone is integral in modulating the sleep-wake cycle, immune-regulatory eļ¬€ect and antioxidant activity. The gut microbiota produces melatonin from tryptophan. This hormone has a favourable eļ¬€ect on microbial population and gut barrier functions. Therefore, any imbalance of gut microbiota directly influences melatonin production and disrupts the circadian rhythm.

9. Evidence from several studies has shown that a significant level of melatonin has been produced by bacteria in the intestinal flora, has a beneficial impact on intestinal barrier functions and a preventive eļ¬€ect in the human brain against neurodegenerative diseases like Multiple sclerosis, Alzheimerā€™s disease and Parkinsonā€™s disease. Gut microbiota dysbiosis has been linked to the development of sleep disorders, autoimmune diseases, metabolic diseases like type 2 diabetes, pro inflammatory responses and neurological disorders.

10. Therefore, there is enough evidence to show that consequences in digestive health have a direct impact on the sleep-wake cycle and vice versa. Research has clearly shown that sleep deprivation can directly impact digestive disorders like gastric esophageal reflux, irritable bowel disorders and many gut health issues. Maintaining a consistent sleep schedule of 7-8 hours can help greatly in reducing the potential risk of many diseases as well as in maintaining a sound gut health. Not to forget that stress management is equally important for maintaining the equilibrium of gut health and sleep patterns. So, an early fiber rich dinner, less screen time, routine exercise, meditation and early sleep habits are essential components to maintain this balance.

Thanks for reading.

Peace and love šŸ™

10 facts: Desquamation or Skin peeling, is it a sign of skin healing ? šŸ™Œ

by drjurisharma, posted in Acne, blackheads, pimples, Dermatology, derma, epidermis, skin care, Eczema, psoriasis, contact dermatitis, cancer, healing, health, meditation, inflammation, disease, physical health, mental health, wellbeing, Petroleum jelly, humidifier, moisturizer, Skin, skin peeling, desquamation, skin healing, wellness

1. Skin peeling is the shedding of the outer layer of the skin called the epidermis. It is a natural process of the body to shed the outer skin that has been damaged due to various causes and replace it with new skin. Skin peeling is a healing process of the skin from damage caused by allergies, skin infections, environmental pollutants, diseases, and treatments like cancer therapy. The medical term for the same is desquamation.

2. As already mentioned, the outer layer of the skin is important as it protects the body from germs and external elements. This epidermis is the thinnest layer and is also responsible for the new skin cells that replace the older and peeled skin. Peeling skin appears scaly, inflamed, red, and even irritated and itching. So, picking may further irritate or infect the new skin that is about to grow.

3. Causes of skin peeling can be many:

ā€¢ Sunburns

ā€¢ Burn: A superficial burn causes the skin to peel as the epidermis is burnt and damaged.

ā€¢ Allergies, rashes, contact dermatitis

ā€¢ Psoriasis, eczema, Pemphigus

ā€¢ Acne

ā€¢ Anti-ageing treatments like chemical peeling, cosmetic creams with harsh chemicals, lotions

ā€¢ Cancer treatments like chemotherapy and radiation therapy.

4. Some of the medical causes which can cause skin peeling that need to be known :

ā€¢ Eczema is a skin condition whose common symptom is skin peeling. This condition can be treatable and controlled but cannot be cured.

ā€¢ Scarlet fever can cause skin peeling and rashes which is contagious.

ā€¢ Scalded Skin syndrome (SSS) or Ritterā€™s disease can cause skin peeling, rashes and large blisters in children under 5 years of age and also in adults with weak immunity. It is caused by a toxin produced by staphylococcal bacteria.

ā€¢ Toxic shock syndrome is a rare and serious condition which might cause skin peeling too. It is usually associated with women due to tampon use.

ā€¢ Kawasaki disease in children can cause skin peeling too along with other symptoms like fever and swollen lymph nodes.

5. Whenever skin peeling happens, the process is slow and should let it shed naturally without interference. However, we can take some steps which will facilitate the process naturally. *Having fluids to keep the skin hydrated. *Apply a hypoallergenic moisturizing cream or a lotion to keep the skin moist and hydrated. *Protect from sun damage by wearing protective clothing.

*Using a humidifier to keep the air hydrated.

6. There is not much concern about skin peeling than its complications which surely need medical attention. Skin peeling is slow and sloughing off takes time. Dehydration of the skin can cause irritation, itching and pain. If there is picking or any complications like bacterial infections, swelling, hives, fever, redness, headache, flu-like sensations, it has to be treated with urgency under medical supervision otherwise it will worsen.

7. Research indicates that the process of desquamation is both natural and essential for maintaining healthy skin. This process, which can be influenced by both natural and medical factors, occurs slowly and serves as a protective mechanism for the skin. It helps remove surface microorganisms, damaged skin cells (corneocytes), and potentially harmful agents, replacing them with fresh, healthy skin.

8.Treatment for skin peeling is generally unnecessary unless there are underlying conditions. The appropriate medication will depend on the specific causes, which may include:

-Antibiotics- Anti-inflammatory medications

– Allergy medications

– Corticosteroids

– Antifungals

– Antihistamines

In cases where no underlying condition is present, using a good petroleum jelly or a non-allergenic moisturizer, along with proper hydration, is usually sufficient to aid in the healing process.

9.Studies show that the process of epidermal desquamation is a healing process with therapeutic relevance. Non-inflammatory skin peeling is typically non-problematic and has a good prognosis. In contrast, inflammatory skin peeling can be associated with atopy and requires medical intervention. Epithelial desquamation involves the shedding of old, dead cells and their replacement with new skin, while keratinization refers to the maturation of skin cells. Both processes are interconnected and essential for maintaining skin integrity.

10. In a nutshell, desquamation is a common process and is not something to be overly concerned about, as it is a natural occurrence. Symptoms such as scaling, dryness, and itching are typical and gradually resolve as the skin is replaced with a new surface. However, it can become a concern in the presence of conditions such as contact dermatitis, eczema, psoriasis, sunburn, ichthyosis, or bacterial infections, which require medical attention.

Thanks for reading.

Peace and love šŸ™

8 facts: Are CoQ10 supplements actually necessary ? šŸ™Œ

by drjurisharma, posted in antioxidant, body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, butter,dairy,inflammatory,disease,cancer,gut health,, cognitive health, Flavonoids, antioxidants, anti inflammatory, healing, health, Heart disease, life, meditation, inflammation, disease, physical health, mental health, wellbeing, Parkinson disease, migraine, fertility, Science, Supplement, Coenzyme, Q10, wellness
CoQ10 supplement

1.We have often encountered a supplement named CoQ10, commonly seen in the drug aisle of a supermarket. Letā€™s know, what exactly CoQ10 is. Well, it is Coenzyme Q10, a fat-soluble, vitamin-like molecule, which is naturally present in every human cell. It is a powerful antioxidant that converts food into energy. Like all other antioxidants, it can neutralize the free radicals and prevent oxidative stress. Therefore, it can prevent us from many chronic health problems and slow down the ageing process.


2.Clinical studies have suggested that CoQ10 plays a significant role in:
It may help in preventing heart-related problems.
Improving the overall immunity.
Improve physical endurance.
Improves male fertility.
Prevent migraine.
Improves blood sugar level in diabetes.
Supports treatment of neuro-degenerative disease like Parkinsonā€™s disease.


3.Evidence-based studies show that people who have a history of heart failure show reduced incidence of heart attack when they take CoQ10 supplements daily along with conventional medications. But then, it has to be prescribed or taken under expert guidance. Several studies have shown similar preventive or improvement levels in cases of heart issues like high cholesterol, high blood pressure, congestive heart diseases and heart damage caused by chemotherapy.


4.CoQ10 supplements have no approval from the FDA or other Drug Regulatory Authorities for the treatment of any medical conditions. However, yet it is easily accessible and available as the over the counter supplements and has been quite popular. It is often recommended as a dietary supplement by many Physicians and Specialists as a supportive therapy to conventional
treatments.

Food sources

5.Naturally dietary sources of CoQ10 intake are enough for overall well-being. Dietary sources are wide variety of whole grains and oily fishes. CoQ10 supplements are not necessary for a healthy individual who has a balanced diet. Supplements of CoQ10 is only necessary for those who suffer from CoQ10 deffeciency, or have health issues like heart disease, migraine, neuro-degenerative
disease or other chronic health conditions. It is not advisable to pick a supplement bottle from the supermarket aisle and start popping unless clinically recommended.

Nuts and seeds

6.As already mentioned, the human body makes enough of CoQ10 as much as it needs. The body content is about 500 to 1500mg and it declines with ageing. The food sources are organ meats, fatty fishes like salmon, sardines, trout, mackerel. As for vegetarians, soya products like tofu, soy milk, and soy yogurt are good food sources. Nuts and seeds, lots of vegetables including broccoli are rich sources of CoQ10.


7.Though CoQ10 supplements do not have major risk or side effects, it is still not advisable to take unless necessary for specific health issues. Some side effects of supplementation can be diarrhea, nausea, heartburn. It may interact with medications like blood thinners with further lowering of blood pressure, or in case of diabetes, subsequent lowering of blood sugar along with hypoglycemic drugs.


8.Due to certain chronic health issues like heart problems, migraine, fertility issues or
neurogenerative conditions, Physicians do recommend CoQ10 supplements. There is no standard dose as such. Depending on the individualā€™s requirement, dosage varies from 60-500 mg daily. The highest dose recommended daily is about 1200 mg. As it is a fat-soluble substance, it is best absorbed with a fatty meal and better if taken at night.

Thanks for reading.

Peace and love šŸ™

10 compelling reasons to consume Flavanoids to combat oxidative stress šŸ™Œ

by drjurisharma, posted in Antioxidant,anti inflammatory, immune boosting, anti cancer, Blog, body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, brain, detoxification, vegetable,, emotional health, Flavonoids, antioxidants, anti inflammatory, Food, Fresh, local, produce, Fruits, veggies, berries, healing, health, life, meditation, inflammation, disease, physical health, mental health, wellbeing, nature, self healing, wellness
  1. Flavonoids are naturally occurring polyphenolic compounds in various deep-coloured fruits and vegetables. There are 6 different varieties of flavonoids, all of which have antioxidant properties and can help the human body to get rid of different toxins and stress. Therefore, including flavonoids in your routine diet can help to get rid of many chronic health conditions.
  2. Dietary Flavonoids are of 6 subtypes :
    Flavanols , Flavones, Flavan-3-ols, Flavanones, Isoflavones, Anthocyanins.
    Coloured fruits, vegetables, and plants are all rich in flavonoids. Naturally, they are found in apples,purple and red grapes, berries, peaches, oranges, cocoa, chocolate, green tea, black tea, chamomile tea, vegetables like broccoli, lettuce, tomatoes, scallions, red peppers and onions. Flavonoids are dark-coloured pigments so they act as natural pesticides and protect the plants from harmful UV rays, bacteria, viruses and harmful insects.

3. Main functions of flavonoids:
ā€¢Powerful antioxidants
ā€¢Fights inflammation
ā€¢Free radical damage and prevent oxidative stress.

ā€¢Anti-haemorrhagic and vasodilatory effects.
ā€¢Certain flavonoids, due to their anti-inflammatory and antioxidant properties prevent cancer cells from multiplying and decrease the risk of some cancers.

4.Research shows that oxidative stress can lead to cellular damage and disease development. So, oxidative stress can cause many disease conditions like cancers, diabetes, cardiovascular diseases like hypertension, atherosclerosis, chronic inflammatory diseases, and neurodegenerative diseases. Flavonoids play an important role in reducing this oxidative stress and free radical damage, thereby preventing cellular damage.

Cocoa (Dark Chocolate)

5.Numerous studies have shown that cancers develop due to oxidative stress, genetic mutations,hypoxia and reduced apoptotic function. Apoptosis, in simple terms, is a normal cellular activity whereby the body tries to eliminate unwanted cells. Flavonoids play an integral part in promoting apoptotic cellular pathways and preventing cancer cells from proliferating and multiplying.

6.Research shows that flavonoids protect the different organs including the liver and brain from free radical damage. Studies show that flavonoids have protective effects of various liver injuries caused by drug and alcohol usage. Since, they are anti-inflammatory, and antitumor, they protect the hepatocytes from inflammation and fibrosis.

7.Flavonoids are a polyphenol group of compounds that can improve and reduce the symptoms of depression and anxiety. Clinical studies in the past have shown that dietary intake of flavonoids can lower the risk of depression. However, further studies are still anticipated to make substantial proof.

8.Flavonoids are best when naturally consumed as all dark-coloured fruits, vegetables, and green tea contain abundant polyphenolic compounds. It should be included in the routine diet for overall
well-being. However, many flavonoid supplements are out in the market. The best supplements are Cucurmin (Tumeric), Green tea, grape seed extract, Resveratrol, Quercetin, hesperidin and Rutin.

9. Toxicity: Intake of natural flavonoids on a daily diet is usually enough. Sometimes, flavonoids supplements are clinically recommended. However, the risk of flavanoid toxicity exists, if someone takes a huge amount of highly potent supplements. It may affect anaemic and elderly patients as flavonoids may bind with non-heme iron. Flavanoid toxicity may cause liver failure, hemolytic anaemia and male reproductive issues. Recommended daily dose of consumption should be around 400-600mg/day.

10.A healthy routine diet rich in flavonoids will provide all the necessary support to the human body to maintain biological activity, provide anti-oxidant effects, reduce oxidative stress and prevent chronic diseases, maintain cardiovascular health and prevent infectious diseases. The key point is that the food readily available to us contains the most effective flavonoids and antioxidants that fortify our health and immune system, making expensive supplements unnecessary

Thanks for reading.

Peace and love šŸ™

Post : Meditation minimizes Inflammation šŸ™Œ

by drjurisharma, posted in brain, cognitive health, emotional health, happy, happiness, wellness, seratonin, dopamine, sunlight, endorphins, healing, health, life, meditation, inflammation, disease, physical health, mental health, wellbeing, mental health, nature, Science, wellness

Hello everyone ! Hope everybody is doing great šŸ™šŸ»

We know by now that chronic inflammation is the commonest cause of various disease state in the body. Inflammation is a natural attempt of our body ‘s immune system to fight against a certain state like infections, injury or toxins which can harm the body. It is a defence system.

When cell damages, your body releases chemicals in the form of antibodies and protein to combat the threat and increases the blood supply to the damaged area to fasten the healing. This usually lasts for a few days and is called acute inflammation. But when the response lingers for a long time can be harmful to the body. In the chronic inflammatory state, the body goes into a constant state of threat. This is the state responsible for many diseases ranging from cancers, asthma, heart diseases, stroke, diabetes and even Alzheimer’s disease.

Chronic inflammation is influenced mainly by chronic stress, anxiety, prolonged infection, injury, autoimmune diseases (like type 1 diabetes, rheumatoid arthritis, Psoriasis and many more), long exposure to toxins and lifestyle factors like smoking, obesity, alcoholism.

Physically, maintaining the health of the body by eating an anti-inflammatory healthy diet (antioxidant-rich ), exercise, Yoga, sleep helps the body greatly to prevent and defend from the inflammatory state.
But then, this is not enough, our environment, our thoughts, feelings, emotions are equally important for healthy mental health, responsible to prevent and defend the body from the inflammatory state. So, how do we maintain a sound, calm mind in spite of all the day to day triggers of stress from our daily grind?

Several types of research have found that meditation-like mindful practises does reduce inflammation by impacting in the brain ‘s functional connectivity. Stress reduction mindfulness practices have shown a marked reduction in inflammatory biomarkers like C reactive proteins.

Learning and practising meditation isn’t rocket science. We don’t need a special session under an expert or Guru to learn to meditate. It is simply a state with the least distraction and freeing the mind from the clutter of thoughts. It is making an effort to put our mind in a relaxed, calm and ā€œnothingā€ state. There are loads of books, reading materials and videos on Youtube and other channels of guiding and teaching you to meditate. But for me, self learning and adopting my method to relax my mind and meditate , works better. Just devote some time for yourself everyday, away from all distractions.

Mindfulness too greatly helps the mind to free from the thoughts clutter. Like meditation, you don’t need to go to a “no thought” state. Instead, you remain fully aware of your surrounding, yet not being reactive to it. It is a basic human ability to be fully present at the moment. Like being simply aware of your breaths, or simply focussing on whatever task you are performing at the moment.

To conclude, whether you may meditate or learn to practise mindfulness, the main purpose is to clear your mind from unnecessary thoughts clutter. This helps your mind greatly from going into chronic stress and overthinking. Maintaining a calm and relaxed mind not only prevent unnecessary inflammation but nurture the physical body and is also self healing.

Thanks for reading.

Blessings and much love to all šŸ’