Tag: life

10 facts to know about the MTHFR gene 🙌

by drjurisharma, posted in Blog, body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, healing, health, life, MTHFR, gene mutations, genetic mutations,, wellness
  1. MTHFR, Methylenetetrahydrofolate reductase, is an enzyme found in human chromosome 1,located exactly in the short arm. It plays a significant role in folate and homocysteine (amino acid) metabolism. Studies have shown that individuals with MTHFR deficiencies can have hyperhomocysteinemia
    with homocystinuria.
  2. Research in the past decades has shown that this enzyme plays a key role in homocysteine metabolism. The deficiency of this enzyme is an inborn error of folate metabolism, which is quite
    rare. Yet, several studies have identified this variant as the most common cause of
    hyperhomocysteinemia and a risk factor for many disorders connected to defective homocysteine
    metabolism.

3.Genetic deficiency of MTHFR is rare, but around 50 cases have already been identified worldwide. Symptoms in such individuals are seizures, developmental delay, neurological impairment, gait dysfunction, and a very high level of homocysteine in urine and plasma. Genetic testing of the gene mutation can be done on a saliva swab and blood sample.

4.Genetic mutations are inherited and acquired from the parents. There are 2 forms of mutations that can occur on the MTHFR gene – C677T and A1298C. If one such variant is present, one is less likely to have health issues but if both variants are present, then the individual is likely to have serious health problems.

Depression

5.Health issues associated with people who have two variants of the MTHFR gene are :
Homocystinuria
Alopecia areata
Spina bifida
High blood pressure
Depression or bipolar disorder
certain cancers
Miscarriages

Pregnancy

6.MTHFR affects pregnancy: Research has shown a link between MTHFR gene variants related to repeated miscarriages. It is important to test for MTHFR gene mutation in women who have suffered unexplained recurrent miscarriages or delivered babies with neural tube defects. Extra folate supplementation and blood thinning administration can be useful to prevent such miscarriages.

7.Diagnosis of MTHFR variant cases is done by testing blood samples and saliva swabs in individuals with a very high level of homocysteine in urine and plasma and vitamin deficiencies of folate, choline, vitamin B12, B6 and riboflavin. MTHFR mutation variant people may not have health issues and can be treated by preventive measures of supplementation of folate and vitamin B and lifestyle changes like a nutritious balanced diet, sleep, exercise and avoiding smoking.

Down’s syndrome

8.Babies and children born with MTHFR mutation variants may present with symptoms within the first year of birth. Such children may have ADHD (attention deficit hyperactivity disorder), autism, impairment of sleep, mood disorder, hyperhomocysteinemia, vitamin, folate deficiency, pediatric stroke, spina bifida and Down’s syndrome.

9.Having gene variants is common in the human population. This particular MTHFR variant gene is common in some ethnicities like in Hispanic individuals. Hispanic races have commonly the MTHFR C677T variant. People with such variants are able to process all types of folate. Research shows that 400mcg of folic acid daily can raise the blood folate level irrespective of whether you are MTHFR genotype.

10.Folate and vitamin B are naturally found in many food sources which should definitely be part of the daily diet. Legumes, leafy greens, citrus fruits, broccoli, Brussels sprouts, bananas, avocados and nuts are rich in folate and should be consumed regularly to have normal levels of folate and promote healthy cell division irrespective of gene mutations.

Thanks for reading.

Peace and love 🙏

Silent Sunday🪻

by drjurisharma, posted in Blog, healing, health, life, nature, Purple , flowers, wellness

Peace and love 🙏

New Year wishes, 2025 🙌

by drjurisharma, posted in body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, celebration, healing, health, life, New year, 2025, peace, happiness, love, joy, anger,, New Year, wishes, health, healing, happiness, positivity, fitness, self healing, wellness
‘ Let your hopes, not your hurts shape your future’ Martin Luther King, Jr

It’s time to letting go of whatever that give us pain, hurt, sadness, anger, regrets and guilt as the year comes to an end. 

Grateful that another 365 days are approaching to renew ourselves with positive energy, change, optimism and peace which may uplift us in this life’s journey. 

Wishing to all my lovely, fellow bloggers, may this New Year 2025 bring immense happiness, peace and favorableness to all of us.

Have a wonderful and blessed year ahead.

Peace and love 🙏

10 tips of eating healthy🙌

by drjurisharma, posted in body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, detoxification, vegetable,, Fresh, local, produce, healing, health, skin, cancer, anti inflammatory, plant, nature, medicine, herb, wellness

Eating healthy is easier and cheaper… Eating healthy isn’t complicated or fussy. In fact , it is the easiest option if we make it a way of life, a …

10 tips of eating healthy🙌

Diwali wishes 2024 🪔

by drjurisharma, posted in Diwali, Diwali, festival, light, Divine, happiness,, Food, healing, health, life, mental health, wellness

We keep moving forward in life because that’s the only option left with us. We may meet new challenges and new obstacles on our path. In this festival of light, may the Divine show us the path, lead us through darkness and protect us in this journey of life and self discovery.

Dear readers, wishing you and your loved ones, a prosperous, joyful and healthy Diwali 2024.

Thanks for reading.

Love and light 🙏

Taming the monkey mind….5 facts 🙌

by drjurisharma, posted in brain, cognitive health, emotional health, healing, health, life, Mind, monkey mind,brain, Mind, thinking,overthinking,wondering mind, self healing, spiritual, wellness

‘Monkey mind’, yes, that’s what the Buddhists called our wondering mind. The more you try to control, the more it wanders. This is the nature of the human mind. It can never remain still. During the day, whenever, we try to be still, the mind races ahead to the future or returns to the past in some old memories. Our mind is always thinking of something or another. Distractions like tasks, jobs, people around, day-to-day stress, entertainment, and social media, all add up to the flickering nature of the mind. Therefore, let’s explore why our mind behaves this way and how we can try to control it, if at all, it’s possible:


1.A wandering mind is quite a normal behaviour and characteristic in nature. The attention shift of the mind from one thought to another is involuntary before even we notice it. In a monotonous daily activity of a boring nature, like studying, in the classroom in case of a student, or doing daily chores, it can happen voluntarily.

2.Studies show that the mind wonders mainly for two reasons: Either the work or activity, we have been doing is not engaging and monotonous and another reason can be that facing obstacles or hard task causes worry and anxiousness.
Sometimes, Scientists, link the wandering nature to creativity, explorative and intuitive mind. However, this becomes problematic. In those times, when we are supposed to be working, we lose focus and attention or think in bed when we are supposed to sleep. Oftentimes, the mind is either daydreaming, imagining things, anxious thoughts worrying about the future or replaying some old memories, stuck in some emotional thoughts.

3.What can be the possible causes of a wondering mind?
*Anxiousness and worrying mind.
*Boring and repetitive activities.
*External distractions like our mobile phones and other gadgets, people around, noises, social media.
*Internal distractions like stress, anger, hurt, sadness. Physical discomfort like fatigue, pain, hunger.
*People with attention deficit disorder have a hyperactive mind.

4.Self-awareness: How can I realise that I have a wondering mind?
Firstly, being aware of your own mental state. Most of the time, if you find yourself, overthinking, worrying, and ruminating thoughts.

Your mind is often, exhausted, being engaged in unproductive thoughts, unable to find solutions to problems or losing your spontaneous problem-solving ability.

Being self-aware, in such a state of mind, can help us to bring about change in our mental state.


5.Taming a wondering mind can be a very difficult task. But, with practice and consistency, everything is possible.

a)Meditation is an effective tool. Again, meditation is’nt easy. Perhaps, sitting still in a quiet place, trying to focus the mind is a hardest task. Focusing on breathing is a commonest method. Other methods can be, focusing or imagining an object like sun, moon, or the ocean. Using a guided mediation or listening to nature sounds, chanting of mantras can be effective.


b)Journaling is a powerful tool to clear the mind. Noting down daily thoughts, thoughts related to job, loved ones, family, future goals, holiday plans, emotional pain, feelings of old memories can be very useful to clear the mind clutter. Writing down can self-help to acknowledge the bothering thoughts and refocus the mind to concentrate on the task at hand.


c)Physical activity like going for a walk, physical movement of the body, legs and hands, watering your balcony plants, spending time in nature, light exercises can be very helpful to reset the mind. Playing an instrument, or listening to a music piece can be rejuvenating to refocus the mind too.

d)Sleep and adequate rest are necessary to clear the mind clutter. Getting a proper goodnight sleep and following a daily sleep routine is mandatory. Making a conscious effort to keep away from our mobile phones, social media distractions, caffeine free, emotional disturbing thoughts, 2-3 hours prior going to bed, can give an adequate sleep.

Thanks for reading.

Peace and love 🙏

Butyrate is the latest buzzword! Is it just a hype or the reality? 10 facts 🙌

by drjurisharma, posted in body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, brain, butter,dairy,inflammatory,disease,cancer,gut health,, butyrate, dairy, curd, yogurt, detoxification, vegetable,, Food, gut health, gut bacteria, hormones, Gastrointestinal, GI tract, healing, health, life, Science, wellness
Butter is a rich source of butyrate

1.Butyrate is a short-chain fatty acid (SFCA) released during the fermentation of dietary fibres by the gut microbiome. It plays an integral part in supporting gut health and overall well-being. It is an energy source for colonocytes which meet about 70% of their needs. Evidence has shown that this SFCA has tremendous health benefits ranging from immunity support, lowering inflammation, preventing cancers and fighting ageing. Hence, it is the latest buzzword, doing rounds in social media and among advertisers.

2.Recent studies have clearly shown that butyrate plays an important role in both the host and microbial functions in gastrointestinal health. It is a crucial energy source for colonocytes. An optimal level of butyrate promotes and maintains a healthy microbiome level, reduces inflammation, and supports colonocyte functions. It has protective actions against certain intestinal diseases like inflammatory bowel diseases and colon cancer.

3.Butyrate has been shown to prevent the process of inflammation in the gut which can be caused by pathogens, the body’s overreaction (allergic reactions) and oxidative stress. Chronic inflammation in the gut occurs when the gut’s immune system is constantly fighting against these pathogens and free radicals causing the immune health to be weakened. Eating a considerable amount of fibres causes to production of an optimal level of butyrate which helps in protecting against this inflammatory process.

Dietary fiber is a good source of butyrate

4.Studies have shown a great impact of butyrate on obesity. Butyrate is found to lower body weight and decrease lipogenesis in the liver and adipose tissues. It increases fatty acid oxidation and prevents fat accumulation in the body thereby reducing obesity. Butyrate is produced by the fermentation of dietary fibres, so it suppresses the food intake and reduces body weight and fat mass.

5.Animal and cell studies have shown that butyrate increases insulin sensitivity, helps in reducing weight gain, and obesity and promotes weight loss. It helps in maintaining blood sugar levels.

Dairy products

6.Another significant property of butyrate has been shown in research that it promotes cell differentiation. Normally, our cells have the ability to change into any specific type of body cells required like liver cells, heart cells, intestinal cells or blood cells. If the cells are not properly differentiated, then, abnormal growth or tumour appears. Butyrate is found to promote cell differentiation.

7.Studies have shown that butyrate plays an important role in the brain-gut connection. It helps in increasing Brain-Derived Neurotrophic Factor (BDNF), removes toxic byproducts from the brain and prevents brain fog. It promotes neuroplasticity and improves rapid eye movement sleep by 70%.

8.Butyrate helps to regulate the blood pressure level. Studies show that the level of butyrate inversely corresponds to the blood pressure level. A higher butyrate level gives a lower blood pressure level while low butyrate may lead to the rise of high blood pressure.

Leafy veggies

9.Sources of butyrate are :
Dietary fibres like vegetables like garlic, onion, tomatoes, beans, peas, leafy vegetables, broccoli. Fruits like bananas, apples, pears, kiwis.
Whole grains like brown rice, oats, wheat, barley, rye and pulses, legumes.
Dairy sources like milk, cheese, butter, and ghee.
Others like dark chocolate, seeds, nuts, and seawood.
Butyrate supplements are available in the form of sodium, calcium/magnesium butyrate but need to be used as per supervision as they may interfere with other medication.

10.It is important to know that consuming full-fat dairy products like butter, Ghee, cheese, and milk are rich sources of butyrate. However, consuming these products can cause the risk of elevating the level of cholesterol in the body as they are rich in saturated fatty acids too. Therefore, the risk of cardiovascular diseases and obesity may rise. So, the key point to be noted while consuming these products is having them in moderation along with lots of dietary fibre and plenty of water can benefit and maintain the balance.

Thanks for reading.

Peace and love 🙏

Wordless Wednesday 🙌

by drjurisharma, posted in healing, health, life, mental health, nature, spiritual, travel, wellness
Greens

Peace and love 🙏

Sunday musings 🙌

by drjurisharma, posted in healing, life, mental health, Uncategorized, wellness

Happy Sunday everyone!

Thanks for reading.

Peace and love 🙏

10 facts about Nigella seeds 🙌

by drjurisharma, posted in body, health, lifestyle, dietary, exercise, herbs, water, liver, stroke, cancer, hepatitis, brain, cognitive health, detoxification, vegetable,, emotional health, Food, hair, healing, health, life, Science, skin, cancer, anti inflammatory, plant, nature, medicine, herb, Uncategorized, wellness


1.Throughout history, Nigella seeds, known scientifically as ‘Nigella Sativa’, have been utilized in a variety of culinary dishes in South Asian and Middle Eastern regions. These seeds grow from a flowering plant. The taste of these tiny black seeds is similar to that of onion and oregano, but they are slightly bitter. They are known for centuries for their immense medicinal and health benefits. They can be utilized in various forms, such as whole, oil, capsules, or powdered form.

2.Nutrition: Packed full of minerals and vitamins, including iron, calcium, zinc, copper, thiamine, phosphorus, folic acid, and many more, it’s a power meal. Useful fatty acids including linoleic, oleic, palmitic, and arachidonic acids make up the seed oil. Thymoquinone, its primary active ingredient, is extremely beneficial to health.

3.Antioxidants: Nigella seeds are full of antioxidants, which can fight free radicals and prevent oxidative stress. Studies show that nigella seeds contain several amino acids like carvacrol, thymoquinone, and 4-terpineol, which are powerful antioxidants. Hence, regular intake of nigella seeds can help protect against a wide variety of diseases, like heart disease, diabetes, cancer, and obesity.

4.Cholesterol: Many studies have shown that taking nigella seeds powder can help to lower LDL cholesterol and increase HDL cholesterol levels. This powerful effect can help the body prevent atherosclerotic diseases and ischaemic heart disease.

5.Brain: Nigella seeds have been shown to have the ability to slow down or prevent the progression of certain neurological inflammation in the brain, including Alzheimer’s disease, epilepsy, encephalomyelitis, depression, and Parkinson’s disease. Some research have also shown that nigella seeds can slow down the progression of dementia and age related memory loss.

6.Anti-cancer: Research has shown that the antioxidant thymoquinone has strong anti-cancer properties. Lung, cervical, pancreatic, prostate, skin, and colon cancers can all be prevented with the use of nigella seeds and their constituents. However, further data and investigation are needed to validate these effects.

7.Anti-bacterial: Studies have demonstrated the anti-bacterial properties of nigella seeds on germs that cause everything from ear infections to pneumonia. Their antibacterial and antibiotic qualities aid in the treatment of skin infections. They can aid in the management of chronic obstructive lung disorders and asthma because of their anti-inflammatory qualities. To manage such problems, people take the oil in capsules. However, further investigation is needed to fully understand these impacts.

8.Skin: Studies have shown that black seed oil can be used routinely to moisturize and skin cleansing. It can help to manage certain skin issues like psoriasis, eczema, vitiligo, pigmentation and wound healing. It can fasten wound healing, repair tissue damage, reduce skin irritation, heal minor burns, scar tissues. It can also help to moisturize hair, reduce hair loss.


9.Dosage: Nigella seeds have been found to have many health and healing properties and is widely been used. It’s available in capsule, powder, tablets, creams, oil, soaps, shampoos and many more forms. It is safe in small doses , about 1-2.5 gm by mouth on daily basis. But, it is recommended to inform your Primary Physician before using it.

10.Side-effects:
*Bleeding disorder: It slows blood clotting, so it is contraindicated in people with bleeding disorders. *

*Since nigella seeds may interfere with metabolism, it is important to inform the treating physician while using them.

*It can slow down uterine contraction so nigella seeds supplementation should not be used during pregnancy.
*Usually it protects the kidneys but excess consumption like 2000-2500mg daily may affect kidney health.
*The best way to minimize the potential side effects is by incorporating nigella seeds paste or oil in very small quantity in meals to enjoy the immense health benefits, these seeds provide.

Thanks for reading.

Peace and love 🙏