Tag: ageing

10 facts about Orexin 🧠

by drjurisharma, posted in brain, cognitive health, emotional health, Food, life, Orexin

Hi everyone ✋

1.The lateral hypothalamus and prefrontal cortex produce a hormone called Orexin, also known as hypocretin. It is produced in two forms like Orexin A and Orexin B. It has various functions related to Central Nervous System. It helps in regulating important functions like sleep-wake cycle, arousal state, energy homeostasis, feeding behaviour, emotions, mood and cognition.


2.Sleep: Orexin is usually released in the daytime and keeps us awake. It stimulates those neurons which in turn help in the release of neurotransmitters like serotonin, dopamine and nor- epinephrine. In case of individuals with orexin deficiency, are usually diagnosed with narcolepsy, insomnia, sleep imbalance, daytime sleepiness and cataplexy.


3.Stress regulator: Orexin is highly responsive to environmental stimuli and our mood. When in stress situations ,the orexin neurons stimulate the body’s response to increase heart rate, blood pressure and disturb the resting state.


4.Obesity: It is a result of the influence of orexin-producing neurons on energy metabolism.Orexin deficiency in the body can lead to slowing down energy metabolism, physical inactivity, and excessive weight gain, even if the calorie intake is low.

5.Mood: Orexin has an influence on mood through its impact on the hippocampus. Abnormal orexin activity has been related to mental health conditions like depression, PTSD, anxiety and addiction. Deficits in orexin influence can result in hippocampus problems such as learning disability and memory deficits, as it also promotes the development of neurons in the hippocampus.


6.Narcolepsy: Orexin helps us stay awake during the day. So, people with orexin deficiency suffer from narcolepsy. They have daytime sleepiness and sleep paralysis. Mostly, these type of individuals can also suffer from cataplexy. The person is unable to move for a short time even if he is awake or about to fall asleep. It is usually occurs in a conscious state of mind and triggered by strong emotions like being angry, or laughing.

7.Alzheimer’s Disease: Several studies show that orexin has direct connection with sleep, cognition and as a stress regular. So it does play a significant impact on Alzheimer’s disease pathology. An increase level of orexin has been found in cerebrospinal fluid of people with Alzheimer’s. So, they usually have circadian cycle disorders, daytime sleepiness and cognition problems. However, researches are still going on for further prospectives of using orexin antagonist receptors as a potential treatment alternative.

8.Heart: Lack of sleep and insomnia have a direct impact on cardiovascular health and hypertension. Studies show that increased levels of orexin stimulation can elevate blood pressure and heart rate. Both orexin A and B receptors have a direct role in the regulation of sympathetic nervous system. Therefore orexin antagonist receptors might be a therapeutic option for hypertension.

9.Orexin levels: High levels of orexin may lead to sleep disorders, stress prone and eating disorders. But lack of orexin or loss of orexin in brain injury may lead to narcolepsy or other sleep disorders. The normal level of orexin found in cerebrospinal fluid in a healthy individual is around 250 – 500 pg/ml.

10.Food: Optimal level of orexin can be provided in a healthy individual by regular intake of fermented food like pickles or sauerkraut. Having excessive sugar or carbohydrate rich food can inhibit orexing production.

Thanks for reading.

Peace and love 🙏

Wordless Wednesday 🍃

by drjurisharma, posted in brain, celebration, cognitive health, emotional health, eyes, life, nature, photography

10 facts of Chicory roots 🪵

by drjurisharma, posted in brain, cognitive health, emotional health, Food, life

Hello everyone ✋


1. Chicory is a tuberous herbeceous root, usually grown in winter. Though it is a native herb from Europe and Asia, but nowadays it widely grown in many areas for its health benefits and as a herbal remedy.

2. Chicory roots are a good source of carbs, minerals, and phytochemicals, including flavonoids. It has been utilized as herbal medicine for generations due to its high nutritional value. Research have shown that it has anti-inflammatory, antibacterial, and antioxidant properties.

3. In modern days, many of its benefits has been scientifically proven. Chicory root is rich in inulin which is a fructose rich fiber and acts as a prebiotic. It promotes growth of healthy bacteria in the gut. Since, it is undigested in the gut when consumed, so it can act as a laxative and relieves constipation.

4. Studies have shown that chicory can contribute to lower blood sugar and helps in insulin resistance. Therefore, it can be an aid in the treatment of diabetes.

5. Other list of benefits of chicory roots are it can promote the weight loss process, improves liver health, boost kidney function by its diuretic properties and may help in treating candida and eczema.

Chicory coffee

6. Since chicory roots are naturally caffeine free, so they have widely been used as a coffee alternative to reduce the intake of caffeine. Repeated consumption of coffee may lead to excess caffeine intake which in turn can cause issues like increasing the level of cortisol and stress.

7. Extensively used method of including chicory in diet is by blending with coffee as chicory coffee, or as herbal tea. It is also integrated in cereals, protein bars and other food items.

8. Like any other food, Chicory roots also have it’s share of side effects like over consumption can lead to allergic reactions, skin rashes, GI symptoms like discomfort, diarrhoea and gall stone.It is contraindicated during pregnancy and lactation.

9. As there is no specific doses of daily consumption of chicory, generally having around 5 gram of inulin in 500ml of chicory coffee in regular diet may not lead to any adverse effects. However, a Physician’s or an expert advice is recommended.

10. Chicory roots have been in ancient cultures for ages as a herbal medicine. History says that it has been in use as a healthy beverage for many centuries for its health benefits.

Thanks for reading.

Peace and love 🙏

Tuesday musings 🌻

by drjurisharma, posted in brain, celebration, cognitive health, emotional health, life, nature, Uncategorized

‘Don’t think what went wrong in the past, don’t plan too much for the future, just think and act at present’ ….

Thanks for reading 🙏

Peace and love 🍃

10 hard facts about Taurine 🙌

by drjurisharma, posted in brain, cognitive health, eyes, Food, life, taurine, Uncategorized

Hello everyone ,

1. Amino Acid :Taurine is found naturally in our body. Chemically, it’s an amino acid or more precisely amino sulphonic acid. Since it is naturally available in the body, it plays a significant part in different bodily functions like metabolism, immunity, nervous system, electrolyte balance, biliary system.

2. Nervous system :Taurine as an abundant amino acid support building up the nervous system, helps in storing memory. As ageing progresses, it’s bodily reserve reduces with age. Due to its decreased levels can be responsible for neurodegenerative diseases like Alzheimers’ or memory deficits.

3. Liver :The liver is supported by taurine mainly to break down cholesterol into bile salts. Bile salts play a crucial role in the digestion and metabolism of fat in the body.

4. Lifespan: Researches show that high taurine levels do have anti-aging effects. From its lower levels contribute to inflammation, diabetes, obesity, hypertension, so, with improved levels of taurine, these risk factors are significantly reduced. Food supplementation of taurine and exercise do contribute to the lifespan.

5. Cell protective agent: Taurine plays a vital role in regulating cell volume, calcium homeostasis, sweeping free radicals and stabilizing the cell membrane.

6. Heart : Studies show that taurine reduces the risk of heart failure by lowering the progression of atherosclerosis. It has a potential vasodilating effect. Taurine supplement in people who have a history of heart failure shows lower levels of cholesterol. Low Taurine levels may be a significant factor in the development of cardiomyopathy.

7. Eye :Studies have shown that taurine is abundant in the retina of the eye. Reduced levels of taurine is linked to eye disorders like glaucoma, retinal degeneration like diabetic retinopathy.

8. Muscle :Studies show that taurine helps to improve muscle power and strength. Taurine appears to help restore muscle injuries, damage, pain and reduce progress in people with muscular dystrophy.

9. Food : Taurine is found in dairy and high sources are mainly meat, chicken and fishes. As for plant based diet, seaweed is a good source of taurine.

10. Dosage : Taurine supplementation is not usually recommended as it is naturally available in the body and in our diet. If prescribed clinically, evidence shows that consumption of 3 gms per day works well without the risk of side effects. Taurine has also been an essential component in energy drinks in case of physical performance. Some infant formulas contain taurine because it is not naturally found in babies as it is in adults.

Thanks for reading.

Peace and love 🙏

Wordless Wednesday 🌷

by drjurisharma, posted in emotional health, life, nature, photography, Uncategorized

Hello everyone 🌻

Pictures taken by me at Keukenhof in Spring 2022.

Thanks 🙏

Peace and love.

10 interesting facts about Melatonin 😴

by drjurisharma, posted in brain, cognitive health, emotional health, eyes, life, nature, Uncategorized

Hello everyone🖖

Melatonin, commonly known as the sleep hormone is responsible for our cicardian rythm. But, it has some fascinating facts to be known.

1. The pineal gland, located at the base of the brain, is known to produce 5% of the total quantity of melatonin. Surprisingly, in all of the cells throughout the entire body, the mitochondria generate the remaining 95% of melatonin.

2. Our body cells’ mitochondria typically serve as the energy-generating organelles. They absorb glucose and oxygen to create water and ATP, which serve as the body’s power source. Free radicals are created during this procedure. However, the free radicals can be neutralised by our body’s defence systems. Melatonin acts as the potent anti-oxidant which causes free radical damage.

3. The melatonin which is produced in the body cells due to the sunlight, especially the infra red rays trigger the release of glutathione and other potent anti-oxidants. Melatonin also has anti -inflammatory properties and anti cancer properties too.

4. Since, melatonin is an effective anti-oxidant, it helps to prevent eye and ear damage. Research shows that it is effective in prevention of age related macular degeneration and retinopathy.

5. Melatonin protects the brain. Melatonin serves to promote the growth of new brain cells and improves memory, according to studies. Melatonin levels were discovered to be low in those with Alzeihmers disease. Thus, it is possible to prevent Parkinson’s and Alzheimer’s disease from becoming severely disabling by increasing melatonin levels.

6. Research shows that melatonin stimulate growth hormone production. Evidences showed that oral administration of melatonin increased the level of growth hormone, two fold times.

7.Melatonin production declines noticeably as we get older. Therefore, in order to maintain melatonin levels in our everyday lives, we must get enough sun exposure during the day and turn off lights at night so that darkness can help to stimulate melatonin production.

8. Sub-cellular melatonin which is produced in the body naturally is more effective than taking melatonin pills. Melatonin pills do work on short term basis and should be taken only if clinically recommended.

9. Aside from the infrared radiation that comes from sunlight, which is typically present in the early morning, other sources of infrared radiation that contribute to a sufficient amount of melatonin production include candlelight and being in front of a fire.

10. Incadescent light bulbs, spending time in greenery parks, outdoors all help to boost melatonin production.

Thanks for reading.

Peace and love 🙏

Self renewal: 10 hard facts 🙌

by drjurisharma, posted in brain, emotional health, eyes, life, nature

Hello everyone 🖖

1. The human body in which each of us lives is made up of around 37 trillion cells, to be precise. And every day, about 1-2 percent of the cells are renewing. So, exactly after 90–100 days, a new “me” appears. We remain so busy with our routine lives that we hardly acknowledge this fact, and many of us are not even aware of it. So, ‘change’ is the constant tune, not just within the universe but also within us.

2. Now that we understand that our bodies undergo transformation on a daily basis, So, the question is: how does this self-renewal occur? Let’s go back to our past a little bit. The human body develops from the human embryo, which is fertilized by an oocyte and a sperm cell. This embryo is made up of stem cells. The stem cells are the basic cells (undifferenciated cells) of the human body, which, through the process of mutation and transformation grow into different cells like nerve cells, bone cells, muscle cells, blood cells and so on. Throughout our lifespan, these stem cells undergo cell division and keep replicating; that’s how self-renewal happens.

3. Under normal physiological self-renewal processes, different cells in the body have differing rates of cell division. So, the replication process of various tissues, organs, and blood cells in the body has a different time frame, like the skin epidermal cells, which can take around 10–30 days, whereas a bone cell takes 3 months, or a hair grows about 1 cm in one month, and so on.

4. Though our body is constantly changing due to the continuous self-renewal process through different cell cycles like shedding the old skin cells, renewal of intestinal cell lining, and growing hair or nails on a routine basis, this isn’t a simpler process. The human body is still very complicated and has exceptions. Some cells, such as those in the brain (cerebral cortex), eyes (such as lenses), and heart, do not change from birth to death.

5. But then, why is self-renewal important and must be maintained? Under normal physiological conditions, stem cells have two functions: proliferation and differentiation. Though stem cells have a natural proliferative capacity throughout our lives, disease conditions can affect their physiological self-renewal ability and behavior due to factors such as damage or an unhealthy lifestyle (obesity, lack of physical activity, smoking, or a poor diet).

6. A lack of an appropriate environment within the body or poor maintenance of the human body might eventually lead to the exhaustion of the capacity of stem cell proliferation, which causes premature aging or tissue atrophy. With aging, stem cell activity, tissue regenerative and haemeostasis is significantly declined.

7. Sometime, due to the unhealthy environment within the body, mutations lead to aggressive stem cell division without going through the natural cell differentiation process. This can lead to abnormal tissue growth or cancer in the body. Therefore, the physiological process of stem cell division and the natural stem cell behavior can be affected by four disease conditions, like degenerative, metabolic, cardiovascular, and inflammatory conditions.

8. Regenerative medicine and therapies have arisen as a result of the discovery that defective self-renewal mechanisms in the body are the root cause of malignancies and abnormal cell proliferation. Many disorders are being treated with regenerative medicines based on stem cells. Recent years have seen a significant increase in the use of stem cell treatment to treat a variety of diseases like cancer and disorders including type 1 diabetes, heart disease, stroke, Parkinson’s, burns, osteoarthritis, by regenerating cells, repairing tissues, and transplanting organs.

9. The fact about regenerative medicine is that, though it has helped many patients around the world, the cost of treatment is quite high as the procedure is complicated and the failure rate is high. Human stem cell treatment requires culturing human stem cells in a laboratory setting for a longer period of time, which is quite difficult.

10. The market is flooded with products that promote cell regeneration, anti-aging, and longevity. The lofty claims made by these items are still quite dubious. But it is true that some supplements do work to improve health, lower inflammation, and increase immunity. But in the end, having a healthy diet, getting enough sleep, a calm mind, and exercising regularly is all that’s necessary for good health.

Thanks for reading.

Peace and love 🙏

Enzymes: 6 amazing facts 🙌

by drjurisharma, posted in Food, life, nature

Hello everyone ! Have a wonderful and safe day. 🙋🏻

Enzymes are an integral part of the body’s metabolism, growth and repair. They are crucial for gut health, the ageing process and maintaining overall good health.

Six facts about the fantastic enzymes :

1.Enzymes are protein or protein-like substances found in our body which acts as a catalyst at a cellular level and speed up the biochemical process of energy production, growth and repair of tissues.


2.Enzymes are specific and are very selective to which substance they bind to and activate the process of breakdown and digestion. Whatever food, we consume, each of the food types stimulate a different set of enzymes.
Carbohydrate stimulates enzyme Carbohydrase like Amylase. The enzyme lactase digests lactose. People who lack lactase suffers from lactose intolerance.
Protein stimulates enzyme Protease like Pepsin, trypsin.
Lipid stimulates enzyme Lipase which digests fat by emulsification.
Some more examples of enzymes are: ATP synthase helps to convert ADP to ATP. Helicase unzips DNA strands.

3. Enzymes are sensitive to temperature and ph change. A slight temperature change can either slow down or speed up the enzyme activity. Large temperature changes can denature and can even lose their function. Similarly, ph changes can directly influence enzyme activity.

4. Enzymes stores in our body can be depleted slowly due to causes like ageing, unhealthy food habits like overprocessing, refined food consumption. Overcooking of food can cause the breakdown of natural enzymes present in the food. Therefore, enzyme deficiency in the body can lead to digestive issues like bloating, gas, food intolerance, anaemia, lethargy and heartburn.

5. There have been multiple enzyme supplements available and marketed commercially with different benefits in the market. But it is essential to know that not enough studies/researches are done to prove either their efficacy or side effects. So, before using the supplements, it is crucial to inform your Physician or else, it may have a drug interaction with your regular medicines currently taken.

6. Certain food rich with natural enzymes which can be consumed but in moderation:
Pineapple has bromolein, and Papaya has papain, and they both are protein enzymes. Avocado has Lipase, and bananas have amylase and maltase. Natural raw honey, wild sprouts (alfa, alfa) and kefir are also rich in digestive enzymes. Fermented food like saurkraut, kimchi is rich in digestive enzymes and even probiotics.

Thanks for reading.

Blessings and much love to all 💐

 

Face ageing: 5 crucial tips 😌

by drjurisharma, posted in Food, life, nature

Hello everyone ! Have a wonderful and safe day 🙋🏻

Skin is the largest organ in the body and is most prominent. So, any kind of changes of ageing can be visible clearly in the skin. The skin, like other tissues, possess the extracellular matrix. This matrix comprises collagen and other structural compounds called Glycosaminoglycans (GAGs) and proteoglycans. All these compounds together contribute to the tightness of the tissues which keep our skin stiff and makes us look younger and radiant.

As we age, we tend to lose more collagen, proteoglycans and GAGs slowly. A research study has shown that another vital hormone produced in the liver called Insulin Growth Factor -1 (IGF-1) is related to facial ageing. These IGF-1 levels are inversely proportional to the levels of serum insulin in the body. When insulin level is high like in case of insulin resistance individuals, the IGF-1 level is low. So, insulin resistance individuals tend to age faster usually. Hyaluronic acid is a lubricant which is also naturally produced by our body which helps the skin and connective tissues to retain the moisture. We tend to lose this lubricant due to ageing and unhealthy food habits.

Facial ageing causes the horizontal and vertical lines to look prominent, thinned skin, loss of elasticity and collagen, loss of tissues and bones in the cheeks, fat atrophy, puffiness around eyes, sagginess around the neck and so on.

Common factors which aggravate the ageing process:

1.Smoking
2.Too much sun exposure causes skin damage. But, daily exposure to 10-15 mins of sunlight is useful for Vitamin D synthesis in the body.


3.Too much chemical-based cosmetic products like cremes, lotions, make up products are harmful.
4.Alcohol /drugs consumption
5.Refined processed food and too much sugar


6.Chronic stress causes high cortisol level.
7.Sedantery lifestyle and lack of exercise.

Specific important ways which prevent facial ageing :


1.Exercise: Most preferably maintaining an active lifestyle with the routine exercise of 30 mins to1 hour is ideal.A particular activity like high-intensity interval training (HIIT) is short periods of 7-10mins of intense exercise with intervals of rest, and low-intensity exercise is beneficial to keep the cortisol level optimum. 

2.Enhance the quality of sleep: Sleep induces the release of HGH, human growth hormone and Insulin growth factor-1, which helps to prevent the breakdown of collagen and proteoglycans.


3.Intemittent fasting: Fasting of at least 16 hours can stimulate autophagy, body’s renewal mechanism, activates the immune system. Fasting increases the antioxidant activity and increase stem cell production.
4: Foods:
Collagen rich foods: These foods are a rich source of collagen, amino acids and hyaluronic acids.
Fermented foods: bone broth, green leafy veggies, caviar or fish roe, citrus fruits, mushrooms and seaweeds. To know more about collagen, please refer to my previous post https://atomic-temporary-162723897.wpcomstaging.com/wp-admin/post.php?post=4448&action=edit

Healthy fats: Omega 3 fatty acids like EPA and DHA found in oily fishes like salmon, tuna, sardines, nuts like walnuts, macadamia, pecan nuts, seeds like chia seeds, flax seeds.
Saturated fats like in grass-fed butter, ghee, coconut oil, olive oil are very helpful.


Organic Acids: Organic acids promote the growth of probiotics in the body, which helps to support the immune system and the cell renewal process. Organic acids found in fermented foods like saurkraut, kombucha are quite known for beauty benefits. The citric acid found in citrus fruits is also vital. Enzyme rich foods: Enzymes are essential for digestion and absorption of proteins in the body. Certain fruits with individual enzymes present in each of them like papaya contain papain. Figs contain ficans. Pineapple contains bromelain and kiwi have actinidain are all-powerful proteolytic enzymes which helps in the polysaccharide metabolism and the digestive process. Fruits are also rich in antioxidants which prevent free radical damage.


Vitamins: Fat-soluble vitamins D, K, E, A are all essential for the prevention of free radical damage and cells renewal process.

5.Essential oils: These natural oils work naturally on the skin by hydrating and moisturizing. Some commonly used oils for beauty purpose are geranium, frankincense, lavender, jojoba, myrrh, rose and rosemary.

So, it is crucial to understand that to have a healthy body, a glowing skin, and healthy hair; it is necessary to correct our food habits and lifestyle rather than spending an enormous amount on cosmetic treatments and beauty products. The approach should be inside out rather than external means.

Thanks for reading.

Blessings and much love to all 💐